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Insomnia is problem in falling or keeping asleep, the absence of restful snooze, or weak high-quality of slumber. Insomnia can be a symptom and not a ailment.pentobarbital decreases amounts of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Solid CYP3A4 inducers can lower panobinostat concentrations by ~70% a